British Air Force Typhoon FGR4s have operated alongside France's air force in a joint strike targeting an subterranean weapons facility in Syrian territory operated by the Islamic State group (IS), according to the British defence ministry.
The location, located using surveillance, was assessed as housing weapons and explosive materials, the statement said, and was located in mountainous terrain just to the north of Palmyra in the heart of Syria.
"Our fighter planes utilized Paveway IV guided bombs to strike a several approach shafts down to the depot... early reports indicate the objective was successfully hit," the MoD said.
There was no sign of any harm to civilians in the attack on Saturday evening and every plane involved returned safely, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as ISIS - established militant control over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates British leadership, and determination to work closely with our allies, to stamp out any revival of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey said.
British military aircraft have carried out overwatch operations over Syrian airspace to "deter any efforts to regroup" of the group after its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of the UK armed forces participating in this mission for their professionalism and their bravery," he said. "They were among thousands of British personnel on duty over Christmas and New Year. This operation, to remove dangerous terrorists who pose a risk to our security, shows how our armed forces are prepared to act, continuously, keeping Britain secure domestically and strong abroad."
Last December, the American forces executed what it described as a "large-scale strike" targeting IS targets in Syria, following an attack resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The UN estimates Daesh still maintains an estimated 5,000 to 7,000 combatants in both countries.